A positive direct or indirect Coombs test may develop during treatment with meropenem. It is used to treat severe infections of the skin, lungs, stomach, urinary tract, blood and brain (eg. eosinophilia, thrombocytopenia, leucopenia, neutropenia, agranulocytosis, haemolytic anaemia, angioedema, anaphylaxis (see sections 4.3 and 4.4), diarrhoea, vomiting, nausea, abdominal pain, antibiotic-associated colitis (see section 4.4). The tables below provide general recommendations for dosing. Enterobacteriaceae Pseudomonas aeruginosa or Acinetobacter spp.) Meropenem 500mg powder for solution for injection or infusion Meropenem 1g powder for solution for injection or infusion meropenem Read all of this leaflet carefully before you start taking this medicine. Faecal elimination represents only approximately 2% of the dose. Before initiating therapy with meropenem, careful inquiry should be made concerning previous hypersensitivity reactions to beta-lactam antibiotics. Meropenem is a white to pale yellow crystalline powder for solution for injection or infusion in vial. Do not freeze the reconstituted solution. pH of the product after reconstitution is 7.3 to 8.3. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3). Continue, 2. Powder for solution for injection or infusion. All reports received were consistent with events observed in the adult population. In individuals with normal renal function, rapid renal elimination will occur. Severe pneumonia including hospital and ventilator-associated pneumonia. CAUTION: To be sold by retail on the prescription of Registered Medical Practitioner only. The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. Merokem 1 gm Injection is safe to use in patients with liver disease. However, it will not treat a viral infection. Tutkimuksia Meropenem Hospiran vaikutuksesta ajokykyyn tai kykyyn käyttää koneita ei ole tehty. Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Meropenem Injection IP stockiest and super stockiest (distributor) in the field of tablets, syrup, otc, antibiotics, life saving and critical care products. b) Each Tablet Contains: Sirolimus 1mg Excipients q.s. The medicinal product is supplied in pack sizes of 1 or 10 vials. Standard aseptic techniques should be used for solution preparation and administration. meningitis). Always use Meropenem exactly as your doctor has told you. After rapid administration (5 minutes or less) the pharmacokinetics are biexponential but this is much less evident after 30 minutes infusion. No specific medicinal product interaction studies other than probenecid were conducted. Meropenem has been shown to penetrate well into several body fluids and tissues: including lung, bronchial secretions, bile, cerebrospinal fluid, gynaecological tissues, skin, fascia, muscle, and peritoneal exudates. Simultaneous administration of antibiotics with warfarin may augment its anti-coagulant effects. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. Severe pneumonia including hospital and ventilator-associated pneumonia. However, the protein binding is so low that no interactions with other compounds would be expected on the basis of this mechanism. The required dose should be administered after completion of the haemodialysis cycle. post-title portfolio-title Meropenem Injection Ip 1G offered by TAPADIYA OVERSEAS is available with multiple payment options and easy delivery. Do not drive if you experience any symptoms that affect your ability to concentrate and react. However, because the compounds in the generic versions have the same molecular structure as the brand-name version, their quality is essentially the same. Discontinuation of therapy with meropenem and the administration of specific treatment for Clostridium difficile should be considered. GMP certified pharmaceutical company fully geared for exports, We are technology driven company supported by extensive F&D department; coupled with well-equipped laboratories and best talented technical officials of the industry. There was no evidence of mutagenic potential in a conventional test battery and no evidence of reproductive toxicity including teratogenic potential in studies in rats up to 750 mg/kg and in monkeys up to 360 mg/kg. No dose adjustment is necessary in patients with hepatic impairment (see section 4.4). Haemodialysis will remove meropenem and its metabolite. In this case, the prepared solution if stored under refrigeration (i.e. No studies on the effect on the ability to drive and use machines have been performed. Meropenem is cleared by haemodialysis with clearance during haemodialysis being approximately 4 times higher than in anuric patients. A study of 12 patients administered meropenem 1000 mg 8 hourly post-surgically for intra-abdominal infections showed a comparable Cmax and half-life to normal subjects but a greater volume of distribution 27 l. The average plasma protein binding of meropenem was approximately 2 % and was independent of concentration. Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg. No dose adjustment is required for the elderly with normal renal function or creatinine clearance values above 50 ml/min. From a microbiological point of view, unless the method of opening/reconstitution/dilution precludes the risk of microbiological contamination, the product should be used immediately. This is because Meropenem can affect the way some medicines work and some medicines can have an effect on Meropenem. There are limited safety data available to support the administration of a 40 mg/kg dose in children as an intravenous bolus injection. Direct antiglobulin test (Coombs test) seroconversion. It is preferable to avoid the use of meropenem during pregnancy. There is no dose adjustment necessary (see section 4.2). Glanders and melioidosis: Use of meropenem in humans is based on in vitro B.mallei and. A study in patients with alcoholic cirrhosis shows no effect of liver disease on the pharmacokinetics of meropenem after repeated doses. Interaction studies have only been performed in adults. In preclinical models meropenem demonstrated activity when plasma concentrations exceeded the MIC of the infecting organisms for approximately 40 % of the dosing interval. The pharmacokinetics of meropenem in neonates requiring anti-infective treatment showed greater clearance in neonates with higher chronological or gestational age with an overall average half-life of 2.9 hours. Small amounts of meropenem have been reported to be excreted in human milk. Merokem 1 gm Injection is an antibiotic. transaminases increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased. It … c) Each Tablet […], Cetirizine Hydrochloride & Ambroxol Hydrochloride Tablets IP 5mg/60mg Taj Pharma, Is generic medicine as safe as branded drugs? If you accidentally use more than your prescribed dose, contact your doctor or nearest hospital straight away. Meropenem belongs to a group of medicines called carbapenem antibiotics. varies across the European Union. Meropenem exerts its bactericidal activity by inhibiting bacterial cell wall synthesis in Gram-positive and Gram-negative bacteria through binding to penicillin-binding proteins (PBPs). Meronem i.v. IV- The recommended dose is 0.5 gm to 2 gm (10 to 40mgkg) by slow infusion, 3 times per day. What Meropenem looks like and contents of the pack. Meropenem 1000mg Allopathic Merowin 1g Injection, For Anti Infective & Common Disease Medicines, Intramuscular Rs 1,000/ Vial Get Latest Price Packaging Size : SINGLE VIAL PACKING In individuals with normal renal function, rapid renal elimination will occur. Do not stop having Meropenem until your doctor tells you to. Meropenem Injection IP 1g Mero 1g full explain with this medicine...?? † Resistance rate≥ 50% in one or more EU countries. TRAIX. Hope this clarifies some of your doubts. The concomitant use of meropenem and valproic acid/sodium valproate/valpromide is not recommended (see section 4.5). This is usually accompanied with a loss of consciousness. This medicinal product contains 90 mg sodium per dose, equivalent to 4.5% of the WHO recommended maximum daily intake of 2 g sodium for an adult. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. In vitro meropenem shows reduced susceptibility to hydrolysis by human dehydropeptidase-I (DHP-I) compared to imipenem and there is no requirement to co-administer a DHP-I inhibitor. Localised clusters of infections due to carbapenem-resistant bacteria have been reported in the European Union. In healthy subjects the mean plasma half-life is approximately 1 hour; the mean volume of distribution is approximately 0.25 l/kg (11-27 l) and the mean clearance is 287 ml/min at 250 mg falling to 205 ml/min at 2 g. Doses of 500, 1000 and 2000 mg doses infused over 30 minutes give mean Cmax values of approximately 23, 49 and 115 μg/ml respectively, corresponding AUC values were 39.3, 62.3 and 153 μg.h/ml. Talk to your doctor if you need 9 or more vials daily for a prolonged period, especially if you have been advised to follow a low salt (sodium) diet. B. pseudomallei susceptibility data and on limited human data. Meropenia™ 1000: Meropenem Injection IP 1000mg, Each vial contains: Meropenem IP (Sterile) equivalent to anhydrous Meropenem 1000mg, sodium carbonate IP(Sterile) equivalent to Sodium (as buffer) 90.2mg. The dose for adults and adolescents should be adjusted when creatinine clearance is less than 51 ml/min, as shown below. Any of these side effects could affect your ability to drive or operate machines. The dose for adults and adolescents should be adjusted when creatinine clearance is less than 51 ml/min, as shown below. Generic medicines are same as branded medicines, even the company that makes branded medicines manufacturers generic version but with a lower price. Each ml of reconstituted solution contains 50 mg Meropenem. Meropenem will be given to you as an injection or infusion into a large vein. European Committee on Antimicrobial Susceptibility Testing (EUCAST) clinical breakpoints for MIC testing are presented below. The measured renal clearance and the effect of probenecid show that meropenem undergoes both filtration and tubular secretion. Meropenem has been shown to penetrate well into several body fluids and tissues: including lung, bronchial secretions, bile, cerebrospinal fluid, gynaecological tissues, skin, fascia, muscle, and peritoneal exudates. This information is intended for use by health professionals, Meropenem 1 g powder for solution for injection or infusion. A positive direct or indirect Coombs test may develop during treatment with meropenem. Similar to other beta-lactam antibacterial agents, the time that meropenem concentrations exceed the MIC (T>MIC) has been shown to best correlate with efficacy. Qualitative and quantitative composition a) Each vial of powder for solution for injection or infusion contains 570.78 mg meropenem trihydrate equivalent to 500mg anhydrous meropenem.