A 52-week study of adapalene 0.3 percent gel (the higher, prescription-only concentration of topical adapalene) found that only 21 percent of users experienced side effects from the treatment, of which the most common were dry skin, scaling and skin discomfort. Of … Head-to-Head. There’s a staggering amount of skincare products designed to help clear the skin off acne, all with varying results. COVID-19: Treatments are being dispatched as usual. All information that appears on this website is intended for information purposes only and It's prescribed generically, under various branded names, and as the active ingredient in medicines including Treclin , and is used across the world to treat various conditions. 1998. If you are interested in a prescription product, Hims will assist in setting up a visit for you with an independent physician who will evaluate whether or not you are an appropriate candidate for the prescription product and if appropriate, may write you a prescription for the product which you can fill at the pharmacy of your choice. Like tretinoin, adapalene is a retinoid. It is similar to many other retinoid substances, but it is a synthetically manufactured substance. Retin-A's active ingredient, tretinoin, is also used to treat fine lines and wrinkles, brighten the complexion, and fade hyperpigmentation (dark marks left by acne breakouts or sun damage). Differin is available over-the-counter ( OTC ). He is a registered pharmacist and the registered manager of our service with the CQC. Approved by the FDA in 1996, adapalene is a relatively new, third-generation retinoid that’s sold as both a prescription medicine and in a lower concentration as an over-the-counter gel for acne prevention and treatment. As with most retinoids, tretinoin can trigger what’s called the tretinoin “purge” — a short period in which acne gets worse before it gets better. Differin (adapalene) is commonly used for treating acne, but, it can cause skin irritation. Long-term studies of tretinoin show similar results, with a low rate of side effects, most of which occur during the first few weeks of treatment and improve over time.Â. Everyone has a different skin type and acne can have multiple causes - a treatment that works perfectly for one person might be less effective or cause greater irritation in another. As members of the retinoid family, they're forms of Vitamin A, which has many roles: It's that last role of Vitamin A that retinoids focus on. No systemic side effects were seen. The secret in Differin Gel (as compared with other retinoid formulations i.e. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. When it comes to dealing with acne, retinoids — a class of medications derived from vitamin A — are some of the most effective tools available.Â, Tretinoin and adapalene are two of the most popular, widely used retinoids on the market. If you’ve started taking tretinoin and experience any of these side effects, it’s best to speak with your healthcare provider immediately. (Tretinoin is also the key ingredient in a number of other brand name retinoids, such as ReFissa and Renova.) Tretinoin is much older than adapalene, coming from the first generation of retinoids and being patented in 1957 before receiving medical approval in 1962. Its common side effects include redness of the skin to an increase in sensitivity to sunlight. Retinoid, Retinol and Adapalene — Today I answer your questions on why I stopped using differin gel. Differin, available as a cream or a gel, is a 0.1% formulation of adapalene prescribed for acne sufferers. Adapalene is one of the newest generation of retinoids on the market along with tazarotene. Skip to: full site navigation. guide. should be used to supplement, not replace, your relationship with your local healthcare professionals. It’s scientifically proven to reduce acne, fight the signs of aging and improve a variety of factors related to skin health. Unlimited visits. Adapalene is a more stable compound that does not break down. Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy. Adapalene is also available over the counter (in a 0.1% formulation versus the 0.3% prescription version). Adapalene vs tretinoin. It's actually the first retinoid to be approved for over-the-counter sale in the US, though it still requires a prescription in the UK. For most people, the best choice is to talk to your healthcare provider about the two medications and work together to choose the best option for your specific needs. In general, irritation was mild, but was both more common and more severe in the tretinoin group vs. the adapalene group. Tretinoin in Retin-A stops the cells from sticking together and increases the mitotic cell division of the cells of the skin. skin irritation or tenderness, a burning sensation, dry skin, itching. Both drugs take a few weeks to several months to start showing benefits, and both can cause a temporary “purge” period in which your skin looks worse before it looks better.Â. $10/month. They have some advantages when compared with older retinoids such as retinol, isotretinoin (Accutane) and tretinoin (Retin-A). Adapalene in Differin not only controls cell development, but also has an impact on keratin formation and inflammation. From an anti-aging perspective, tretinoin is the better choice for most people, with a great track record of reducing wrinkles, hyperpigmentation and other signs of skin aging. Important: This email goes to a third party - never send personal, medical, or health information to this address. Restrictions apply. Regulating epithelial tissue (e.g. Because of this, it may not be recommended first if your goal is to reduce the visibility of wrinkles, creases or pigmented spots.Â. Here's the important takeaway: Treclin is more expensive, but it is stronger than Differin and has antibiotic properties. On the whole, studies comparing tretinoin and adapalene typically find that tretinoin is slightly more effective as an acne treatment. Most tretinoin users start by using a cream or gel with a low to moderate concentration and adjust their tretinoin dosage based on their results and side effects.Â. Long term, both drugs are effective and safe. Tazorac or Tazret is a form of vitamin A called tazarotene at 0.1% or tazarotene at 0.05%. Used through the 1960s to treat a variety of skin disorders, tretinoin was first discovered as a potential treatment for acne in 1969, and in 1971 became the first retinoid approved by the FDA to help treat acne vulgaris. (adapalene vs tretinoin vs tazarotene) Dr. Katherine Mcgraw answered. Find more information here. ABSM Healthcare Ltd (Company Reg. 025% gel in the topical treatment of acne vulgaris. {{{ result._highlightResult.name.value }}}, {{{ condition._highlightResult.name.value }}}, adapalene is less likely to cause further irritation, but tretinoin is more potent, https://www.practiceupdate.com/content/azelaic-acid-vs-adapalene-in-treatment-of-female-adult-acne/19574, https://www.ncbi.nlm.nih.gov/pubmed/25399481, https://www.medicines.org.uk/emc/files/pil.285.pdf, https://www.medicines.org.uk/emc/files/pil.920.pdf, https://www.ncbi.nlm.nih.gov/pubmed/20488582, Charity & Corporate Social Responsibility. If you can't find what you are looking for, please contact our support team on 0333 2200 519. Differin and Retin-A perform the same basic … You can also learn more about tretinoin in our Tretinoin 101 guide, which covers everything from the development of tretinoin to its potential side effects, common brand names and more.Â. The Independent Pharmacy, Unit 3 Heston House, 7-9 Emery Road, Brislington, Bristol, BS4 5PF. More than 70% of patients in both groups had complete clearance or marked improvement. Because of this, it isn't always the best option. It’s sold over the counter and by prescription and tends to be slightly less irritating to the skin than tretinoin, making it worth considering if you have sensitive, easily-irritated facial skin.Â, Overall, both tretinoin and adapalene work well to remove and prevent acne. This means that if you have severe or persistent acne, you may get better results from tretinoin than by using a .1 percent, over-the-counter form of adapalene. Did you know you can search from anywhere on the site? During this period, your skin can feel more sensitive than normal. Adapalene: If you’re struggling with acne, this retinoid is a good choice. The most common is an increase in skin sensitivity and dryness, particularly during the first few weeks of treatment. Because Treclin already contains an antibiotic, it should not be used alongside any other treatments. We use website cookies to ensure that you receive the best experience. Aklief (trifarotene) Cream and Differin Gel are retinoids indicated for the topical treatment of acne vulgaris.. Differin Gel is available over-the-counter ().. Side effects of Aklief Cream and Differin Gel that are similar include application site reactions (such as irritation, itching, pain, redness, dryness, stinging/burning, discoloration, rash, swelling, and lesions) and worsening of acne. Tretinoin vs. Adapalene Scientists have performed several studies comparing the effectiveness of tretinoin to that of adapalene. Talk to a doctor now. Unlike the retinoid tretinoin (Retin-A), adapalene has also been shown to retain its efficacy when applied at the same time as benzoyl peroxide due to its more stable chemical structure. Second, adapalene has a more stable chemical structure than tretinoin, making it okay to use alongside other acne medications such as benzoyl peroxide.Â, Studies show that adapalene is effective at treating acne. Did differin stop working for my acne? Irritation, itching, scaling, pain, dryness, skin discolouration or abnormal redness at the site of application. A comparison of Differin and Tretinoin, both Retinoids, and which one is best for Acne, Ageing, etc. As soon as I moved up to 0.05% Tret the purge and peeling started. Why did I switch to tretinoin? Treclin, however, is a medicinal gel containing two active ingredients: a 0.025% concentration of tretinoin, and a 1% concentration of clindamycin (a strong antibiotic). Blog » Retin-A VS Retin-A MICRO ... Adaferin is a form of tretinoin called adapalene at 0.1%. In clinical studies, adapalene has shown superior tolerability to other topical prescription retinoids, meaning Differin is gentler on your skin, while still effective. adapalene vs tretinoin. One of the biggest meta-analyses found that adapalene is more effective than tretinoin and better tolerated. Tretinoin and adapalene are both highly effective at treating acne. A recent meta-analysis of five well-controlled studies involving more than 900 patients found the efficacy of adapalene 0.1% gel (Differin, Galderma) to be comparable to that of tretinoin 0.025% gel (Retin-A, Valeant). Though it's not yet understood exactly how these treatments reduce acne symptoms, testing has suggested a fairly simple account of how they differ: adapalene is less likely to cause further irritation, but tretinoin is more potent. Accept, {{{ result.pack_size }}} for {{{ result.condition }}}, {{ condition.description | descriptionDisplay }}, Our support team can help via phone 0333 2200 519 or email. Both retinol and adapalene are retinoids, but only adapalene is FDA-approved to treat acne. Simply press 's' on your keyboard and our quick search tool will appear. ABSM Healthcare Ltd (ZA024585) & Red Label Medical Ltd (ZA030687) is registered with the Information Commissioner's Office to protect your data. Are you interested in using tretinoin to prevent acne and reverse the signs of aging? Adapalene is a newer drug that’s slightly less effective at treating acne than tretinoin. In the United States, it’s sold as a prescription medicine, meaning you’ll need to speak to a healthcare professional before you can buy it from a pharmacy.Â, As an acne and anti-aging treatment, tretinoin is typically sold as a topical cream or gel. The former is the basis of Differin, while the latter is synonymous with Retin-A. This usually resolves itself after a few weeks of consistent use, not unlike the tretinoin “purge” period. However, it has several characteristics that make it quite a unique medication when compared to tretinoin. Furthermore, photodegradation of the molecule is less of a concern in comparison to tretinoin and tazarotene . That's why we've created this page, comparing various common acne treatments to give you the information you need. Acne is one of the most common skin conditions in the world. In one study, between 69 percent and 74 percent of patients given adapalene experienced “dramatic reductions” in inflammatory and non-inflammatory acne lesions. as an acne treatment. Adapalene, a derivative of napthoic acid, possesses similar biological properties of tretinoin, but has higher lipophilicity and increased photostability (i.e., stability in light). Tretinoin may break down when used in combination with benzoyl peroxide (for those with acne) and adapalene (a synthetic retinoid). Accordingly, numerous clinical trials have compared adapalene and tretinoin in the management of acne vulgaris and concluded that tretinoin 0.05% gel exhibits a greater anti-acne efficacy than adapalene 0.1% gel, but has higher skin irritation potential. The original intent of retinoids was actually used to treat … Scott is one of the two founders of The Independent Pharmacy. Tretinoin (Retin-A, generic), tazarotene (Avage, Tazorac), and adapalene (Differin) are prescription retinoids. In 2016, 85 percent of the people participating … Despite the incredibly similar names, Retin-A and Retin-A Micro aren't exactly alike. Unlike tretinoin, adapalene does not bind to proteins within the cell. Here's how they differ: Which is best all comes down to the severity and nature of your acne symptoms - we can assess your case and guide you towards the most suitable treatment. Suffering from acne is frustrating enough - you shouldn't have to deal with the further frustration of browsing countless treatments without knowing what makes them different. see our policies and terms and conditions at the bottom of every page. In the same review linked above, researchers found that tretinoin has a “higher skin irritation potential” when used as a long-term acne prevention treatment. Because of this, if you have sensitive skin that gets irritated, itchy or uncomfortable easily, you may be better suited for the less irritating nature of adapalene over tretinoin. Though it's also aimed at moderate acne, it's certainly a stronger treatment than Differin. Always talk to your doctor about the risks and benefits of any treatment. The Independent Pharmacy is an online pharmacy and online doctor service is owned and operated by Compare Differin vs. Renova Head-to-head comparisons of medication uses, side effects, ratings, and more. We'll help you find the right choice for your unique skin! Adapalene is found at a concentration of 0.1% or 0.3% in Differin Gel. This drug has risks. Differin contains Adapalene and Retin-A contains Tretinoin.